For starters, the answer to the question in the title of this thread is definitely yes.
I have never seen it done consistently across an entire house, but I have seen several individual exhibits that really stood out to me as a creative and effective way to display reptiles. If a zoo were to take inspiration from some of these exhibits, and build an entire House in their image, that could be what be what you are looking for. Like
@Fallax , I hope that London's upcoming House could be a similar ordeal, but until it opens, the best I can do is provide a list of some of the best examples and concepts that I have personally seen.
Mixed-species Lineups:
Creative and unusual mixed-species exhibits are always entertaining. Zurich and Hagenbeck both mix Rio Fuerte Beaded Lizards and Colorado River Toads, with the latter also throwing Common Chuckwalla into the mix. The best zoo which I have personally seen in this regard, however, is Antwerp - Caiman Lizard, Weberhorst's Sailfin Lizard and three species of freshwater turtle share one lovely enclosure with underwater viewing, while Cane Toad share with Green Tree Python, Long-nosed Frog share with Crocodile Skink, Madagascar Tree Boa share with Radiated Tortoise and (the highlight for me) American Alligator share with Black Iguana. The iguanas are offered a multitude of branches and trees to escape to, and since they spend almost all of their time up there, while the alligators are in the pool or on the sand, it hardly feels like a mix. But in a way, watching two different ways of life side-by-side is just as fascinating.
@KevinB - American Alligator / Black Iguana enclosure at Antwerp Zoo.
Open-fronted Enclosures
Certain animals can be held in an entirely open-fronted enclosure, designed in such a way that they are very likely to escape, but should they chose to do so, they are mostly harmless anyways. The best example that I have seen here is in the Exotarium at Zoo Zurich (the building is not entirely devoted to reptiles, but one room is, essentially a smaller reptile house). The milk frog enclosure has a glass roof, making it very bright, while the visitor corridor is extremely dark, with the light gradient usually being enough to keep them within, and I am sure that the noise of the corridor also plays a role. However, in a way, this enclosure adds to the argument presented by
@dillotest0 above that, given that herptiles aren't all that active anyways, you might as well display them in a smaller space where they are more likely to be seen. I personally had no luck finding them in this massive space, although photos on the gallery suggest that it is possible.
@Kalaw - Amazon Milk Frog enclosure at Zoo Zurich.
Forcing You To Look:
Similar to the Marwell enclosure mentioned upthread, many zoos have offered their herptiles enormous, well-landscaped spaces where they are near impossible to find, but with some looking, can reliably be spotted, with the naturalism of their location only adding to the satisfaction. Back when Bristol was open, they did this very well with Trinidad Stream Frogs, who had access to the land portion of the Malaysian Giant Pond Turtle enclosure, the abundance of moss and the cracks in the rockwork at the far end offering them ample hiding spots, but it was possible to see them. Chester arguably does this even better, with Trinidad Stream Frogs free-ranging in their Butterfly House, which (coupled with the multitude of pathways through the house to chose from) encourages you to go out of your way looking for frogs, and I spent far longer than I care to admit doing so. But of course, since butterflies are the focus of the walkthrough, it wouldn't work so well in a Reptile House.
@gulogulogulo - former Trinidad Stream Frog / Malaysian Giant Pond Turtle enclosure at Bristol Zoo.
Imagery:
When it comes to telling a conservation message, haunting images are perhaps the best way to do so. London Zoo once did this with Annam Leaf Turtles, putting them in a kitchen-like setting with cooking pots and turtle shells on the walls, and a Vietnamese menu beside the sign, to show how cooking turtles in Vietnam is endangering them. It was very powerful, but it was perhaps taken a bit too far, almost coming across as cultural appropriation. Enclosures like these can be very powerful, but finding a balance is difficult. Eventually, they removed the turtles, some of the cooking items, and the controversial menu, in favour of more turtle shells, turning it into a museum of sorts with a more subtle conservation message. This enclosure, and many others like it, have been thoroughly discussed elsewhere on this site, so I will not speak any further of it - but I will say that, in a way, I am glad this enclosure is gone.
@devilfish - former Annam Leaf Turtle enclosure at London Zoo.
Feeding and Talks:
Another subject that was touched on upthread, feeding and talks are just as good a way with reptiles as they are with mammals of encouraging greater activity and entertaining visitors. And, when done well, they can be even better. At Crocodiles of the World, over 30 Nile and Morelet's Crocodiles share the same pool, and when they are fed with poles, seeing huge crocodiles leap out of the water in an open-topped enclosure can be terrifying and memorable. Of course, given the size of the pool, it does take up a lot of space, but there is still enough space in the Crocodile House for 5 (if memory serves) other crocodilian species, so it could definitely work in a Reptile House.
@Bwassa - Nile Crocodiles being fed at Crocodiles of the World